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I recently purchased the mGluR5 positive modulator, CDPPB, from you and have a question regarding its storage following reconstitution. Upon receiving the product, I reconstituted it in DMSO (@10 mM), and have been keeping it in the refrigerator (+4 deg C). The product appeared to work well the first few times I used it, but now does not appear to be doing anything. I am wondering if the repeated freeze/thaw cycling from removing the CDPPB stock solution from the refrigerator could be having a negative impact on the drug? Do you have any information, or experience regarding this? Would I be better served to aliquot the drug out, so as to minimize any freeze/thaw issues?
Asked on Feb 27 2012
Thank you for contacting Abcam.For storage purposes we do have the following recommendation on the datasheet " Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour."
As you stored your solution already made up in DMSO at 4C, this could explain why the product is no longer working. However as a gesture of good will we would like to send a replacement vial of 10 mg.
If you could provide me with the original Abcam order number, I will be happy to send you the replacement.
I look forward to your reply.
Abcam Scientific Support
回复于 Feb 27 2012