FITC荧光Anti-CD8抗体[LT8] (ab28010)
Key features and details
- FITC Mouse monoclonal [LT8] to CD8
- Suitable for: Flow Cyt
- Reacts with: Human, Rhesus monkey
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
概述
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产品名称
FITC荧光Anti-CD8抗体[LT8]
参阅全部 CD8 一抗 -
描述
FITC荧光小鼠单克隆抗体[LT8] to CD8 -
宿主
Mouse -
偶联物
FITC. Ex: 493nm, Em: 528nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human, Rhesus monkey -
免疫原
Tissue, cells or virus corresponding to Human CD8. normal human blood lymphocytes.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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纯度
Ion Exchange Chromatography -
纯化说明
Ion exchange chromatography. -
克隆
单克隆 -
克隆编号
LT8 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG1 -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab28010于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt |
1/1 - 1/5.
10µl of the working dilution for 106 cells or 100µl human whole blood. |
说明 |
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Flow Cyt
1/1 - 1/5. 10µl of the working dilution for 106 cells or 100µl human whole blood. |
靶标
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功能
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. -
疾病相关
Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. -
序列相似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻译后修饰
All of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 925 Human
- Entrez Gene: 698329 Rhesus monkey
- Omim: 186910 Human
- SwissProt: P01732 Human
- Unigene: 85258 Human
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形式
CD8 beta tissue specificity: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells. CD8 beta PTM: Phosphorylated as a consequence of T-cell activation. -
别名
- CD8 antibody
- CD8 antigen, alpha polypeptide (p32) antibody
- CD8a antibody
see all
图片
数据表及文件
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Datasheet download
文献 (6)
ab28010 被引用在 6 文献中.
- Hernández-Castro JA et al. Two-level submicron high porosity membranes (2LHPM) for the capture and release of white blood cells (WBCs). Lab Chip 19:589-597 (2019). PubMed: 30648711
- Son D et al. Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus. Oncol Lett 17:379-387 (2019). PubMed: 30655778
- Di N et al. Effect of combined propofol-sevoflurane anesthesia on immune function in pediatric patients with acute lymphoblastic leukemia. Oncol Lett 18:35-42 (2019). PubMed: 31289469
- Bacac M et al. A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors. Clin Cancer Res 22:3286-97 (2016). PubMed: 26861458
- Belharazem D et al. cFLIP overexpression in T cells in thymoma-associated myasthenia gravis. Ann Clin Transl Neurol 2:894-905 (2015). Flow Cyt ; Human . PubMed: 26401511
- Elkord E et al. Differential CTLs specific for prostate-specific antigen in healthy donors and patients with prostate cancer. Int Immunol 17:1315-25 (2005). PubMed: 16141246