Anti-CD73抗体(ab115289)
Key features and details
- Rabbit polyclonal to CD73
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-CD73抗体
参阅全部 CD73 一抗 -
描述
兔多克隆抗体to CD73 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide corresponding to Human CD73 (C terminal) conjugated to keyhole limpet haemocyanin.
Database link: P21589 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term. -
存储溶液
pH: 7.4
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab115289于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/100 - 1/500. Predicted molecular weight: 63 kDa.
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IHC-P | (2) |
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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WB
1/100 - 1/500. Predicted molecular weight: 63 kDa. |
IHC-P
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. -
疾病相关
Defects in NT5E are the cause of calcification of joints and arteries (CAJA) [MIM:211800]. A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands. -
序列相似性
Belongs to the 5'-nucleotidase family. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 4907 Human
- Entrez Gene: 23959 Mouse
- Omim: 129190 Human
- SwissProt: P21589 Human
- SwissProt: Q61503 Mouse
- Unigene: 153952 Human
- Unigene: 244235 Mouse
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别名
- 5' NT antibody
- 5' nucleotidase (CD73) antibody
- 5' nucleotidase precursor antibody
see all
图片
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Immunohistochemistry image of formalin-fixed, paraffin-embedded Human placenta tissue stained with ab115289 at 10 µg followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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Anti-CD73 antibody (ab115289) + Mouse brain tissue lysate
Predicted band size: 63 kDa
数据表及文件
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Datasheet download
文献 (5)
ab115289 被引用在 5 文献中.
- Tripathi A et al. Prognostic significance and immune correlates of CD73 expression in renal cell carcinoma. J Immunother Cancer 8:N/A (2020). PubMed: 33177176
- Meng Y et al. The metabolic syndrome alters the miRNA signature of porcine adipose tissue-derived mesenchymal stem cells. Cytometry A 93:93-103 (2018). PubMed: 28678424
- Eirin A et al. Integrated transcriptomic and proteomic analysis of the molecular cargo of extracellular vesicles derived from porcine adipose tissue-derived mesenchymal stem cells. PLoS One 12:e0174303 (2017). PubMed: 28333993
- Yu YI et al. Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma. Oncol Lett 9:2485-2494 (2015). PubMed: 26137095
- Pagnotta SM et al. Ensemble of gene signatures identifies novel biomarkers in colorectal cancer activated through PPAR? and TNFa signaling. PLoS One 8:e72638 (2013). IHC . PubMed: 24133572