Anti-C5a-R抗体[10/92] (ab117579)
Key features and details
- Rat monoclonal [10/92] to C5a-R
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG2a
Related conjugates and formulations
概述
-
产品名称
Anti-C5a-R抗体[10/92]
参阅全部 C5a-R 一抗 -
描述
大鼠单克隆抗体[10/92] to C5a-R -
宿主
Rat -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse C5a-R. RBL-2H3 transfected cells
-
阳性对照
- Mouse Kidney tissue.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
-
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
10/92 -
同种型
IgG2a -
研究领域
相关产品
-
Alternative Versions
-
Compatible Secondaries
-
Conjugation kits
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab117579于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
Use a concentration of 10 µg/ml.
|
说明 |
---|
IHC-P
Use a concentration of 10 µg/ml. |
靶标
-
功能
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
翻译后修饰
Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist. -
细胞定位
Cell membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 12273 Mouse
- SwissProt: P30993 Mouse
- SwissProt: Q3TZ86 Mouse
- Unigene: 247623 Mouse
-
别名
- ANAPHYLATOXIN RECEPTOR antibody
- C5a anaphylatoxin chemotactic receptor antibody
- C5a anaphylatoxin receptor antibody
see all
图片
数据表及文件
-
Datasheet download
文献 (4)
ab117579 被引用在 4 文献中.
- Hu X et al. Respiratory Syncytial Virus Exacerbates Kidney Damages in IgA Nephropathy Mice via the C5a-C5aR1 Axis Orchestrating Th17 Cell Responses. Front Cell Infect Microbiol 9:151 (2019). PubMed: 31134161
- Song D et al. Complement C5a receptor knockout has diminished light-induced microglia/macrophage retinal migration. Mol Vis 23:210-218 (2017). IHC-Fr ; Mouse . PubMed: 28442885
- Hu X et al. Respiratory Syncytial Virus Exacerbates OVA-mediated asthma in mice through C5a-C5aR regulating CD4+T cells Immune Responses. Sci Rep 7:15207 (2017). IHC . PubMed: 29123203
- Li G et al. Neuroprotective effects of argatroban and C5a receptor antagonist (PMX53) following intracerebral haemorrhage. Clin Exp Immunol 175:285-95 (2014). PubMed: 24117111