Anti-BNP抗体[50E1] (ab20984)
Key features and details
- Mouse monoclonal [50E1] to BNP
- Suitable for: ELISA, ICC/IF, WB, Sandwich ELISA
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-BNP抗体[50E1]
参阅全部 BNP 一抗 -
描述
小鼠单克隆抗体[50E1] to BNP -
宿主
Mouse -
特异性
ab20984 detects Human BNP and proBNP. -
经测试应用
适用于: ELISA, ICC/IF, WB, Sandwich ELISAmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human BNP conjugated to bovine serum albumin.
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表位
ab20984 binds to epitope aa 26-32 of Brain natriuretic peptide 32 (CKVLRRH). -
常规说明
This product has switched from ascites to TCS on 29th June 2020. Stock up to lot GR3225984 has been generated from ascites.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
50E1 -
骨髓瘤
Sp2/0 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab20984于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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ICC/IF |
Use at an assay dependent concentration. PubMed: 21482747
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WB |
Use at an assay dependent concentration.
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Sandwich ELISA |
Use at an assay dependent concentration.
Can be used as capture antibody |
说明 |
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ELISA
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. PubMed: 21482747 |
WB
Use at an assay dependent concentration. |
Sandwich ELISA
Use at an assay dependent concentration. Can be used as capture antibody |
靶标
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相关性
Brain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. BNP belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C type natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic peptides (eleven of the 17 amino acid residues are homologous in the ring of each of the natriuretic peptides). BNP is a 32 amino acid peptide with disulfide bond between the cysteine residues Cys10 and Cys26. In earlier studies it has been demonstrated that BNP concentration in blood increases with the severity of congestive heart failure. Quantitative measurement of BNP in blood provides an objective indicator of congestive heart failure severity. -
细胞定位
Secreted -
数据库链接
- Entrez Gene: 4879 Human
- Omim: 600295 Human
- SwissProt: P16860 Human
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别名
- BNP(1-28) antibody
- BNP(1-29) antibody
- BNP(1-30) antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab20984 被引用在 3 文献中.
- Gong Y et al. Improved LFIAs for highly sensitive detection of BNP at point-of-care. Int J Nanomedicine 12:4455-4466 (2017). PubMed: 28670119
- Tae HJ et al. Cardiac remodeling in the mouse model of Marfan syndrome develops into two distinctive phenotypes. Am J Physiol Heart Circ Physiol 310:H290-9 (2016). PubMed: 26566724
- Tonne JM et al. Secretion of glycosylated pro-B-type natriuretic peptide from normal cardiomyocytes. Clin Chem 57:864-73 (2011). WB, ICC/IF ; Human . PubMed: 21482747