Anti-Apolipoprotein B抗体(ab20737)
Key features and details
- Rabbit polyclonal to Apolipoprotein B
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Apolipoprotein B抗体
参阅全部 Apolipoprotein B 一抗 -
描述
兔多克隆抗体to Apolipoprotein B -
宿主
Rabbit -
特异性
Cross-reacts with Apo B48 and B100. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Full length native protein (purified) corresponding to Mouse Apolipoprotein B. Apolipoprotein B48 purified from pooled mouse plasma very low-density lipoprotein.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
纯化说明
Heat inactivated. Product is 0.22um filtered. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab20737于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (2) |
1/500. Predicted molecular weight: 515 kDa.
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说明 |
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WB
1/500. Predicted molecular weight: 515 kDa. |
靶标
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功能
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. -
疾病相关
Hypobetalipoproteinemia, familial, 1
Familial ligand-defective apolipoprotein B-100
Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia. -
序列相似性
Contains 1 vitellogenin domain. -
翻译后修饰
Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle. -
细胞定位
Cytoplasm. Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 338 Human
- Entrez Gene: 238055 Mouse
- Omim: 107730 Human
- SwissProt: P04114 Human
- SwissProt: E9Q414 Mouse
- Unigene: 120759 Human
- Unigene: 221239 Mouse
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别名
- Apo B 100 antibody
- Apo B antibody
- Apo B-100 antibody
see all
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (79)
ab20737 被引用在 79 文献中.
- Luo F et al. Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats. Cell Mol Gastroenterol Hepatol 13:879-899 (2022). PubMed: 34923175
- Gomes D et al. Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis. J Lipid Res 63:100174 (2022). PubMed: 35101425
- Zhang S & Jin Z Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Containing Long Noncoding RNA NEAT1 Relieve Osteoarthritis. Oxid Med Cell Longev 2022:5517648 (2022). PubMed: 35480871
- Tsumita T et al. The oxidized-LDL/LOX-1 axis in tumor endothelial cells enhances metastasis by recruiting neutrophils and cancer cells. Int J Cancer 151:944-956 (2022). PubMed: 35608341
- Ramms B et al. Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering. JCI Insight 7:N/A (2022). PubMed: 35653195