Anti-Amylin/DAP抗体(ab103580)
Key features and details
- Rabbit polyclonal to Amylin/DAP
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Amylin/DAP抗体
参阅全部 Amylin/DAP 一抗 -
描述
兔多克隆抗体to Amylin/DAP -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein within Human Amylin/DAP aa 1-100. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: NP_000406.1 -
阳性对照
- Human spleen tissue lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab103580于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 10 kDa.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 10 kDa. |
靶标
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功能
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. -
序列相似性
Belongs to the calcitonin family. -
结构域
The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation. -
翻译后修饰
Amyloid fibrils are degraded by IDE. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 3375 Human
- Omim: 147940 Human
- SwissProt: P10997 Human
- Unigene: 46835 Human
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别名
- Amylin antibody
- DAP antibody
- Diabetes associated peptide antibody
see all
图片
数据表及文件
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Datasheet download
文献 (3)
ab103580 被引用在 3 文献中.
- Yang Y et al. Pramlintide: A Novel Therapeutic Approach for Osteosarcoma through Metabolic Reprogramming. Cancers (Basel) 14:N/A (2022). PubMed: 36077845
- Burillo J et al. Human amylin aggregates release within exosomes as a protective mechanism in pancreatic β cells: Pancreatic β-hippocampal cell communication. Biochim Biophys Acta Mol Cell Res 1868:118971 (2021). PubMed: 33515645
- Venkatanarayan A et al. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature 517:626-30 (2015). WB . PubMed: 25409149