Anti-Activin A Receptor Type IB/ALK-4抗体[MM0054-11A7] (ab78415)
Key features and details
- Mouse monoclonal [MM0054-11A7] to Activin A Receptor Type IB/ALK-4
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-Activin A Receptor Type IB/ALK-4抗体[MM0054-11A7]
参阅全部 Activin A Receptor Type IB/ALK-4 一抗 -
描述
小鼠单克隆抗体[MM0054-11A7] to Activin A Receptor Type IB/ALK-4 -
宿主
Mouse -
特异性
ab78415 detects Activin A Receptor Type IB (ALK4). No cross reactivity was found to Activin A Receptor Type IA (ALK2). -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment corresponding to Human Activin A Receptor Type IB/ALK-4 (extracellular).
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阳性对照
- WB: Human embryonic tissue lysate. IHC-P: Human placental tissue.
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常规说明
This antibody was produced from a hybridoma (mouse myeloma) fused with spleen cells from an immunized mouse.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
Primary antibody说明
This antibody was produced from a hybridoma (mouse myeloma) fused with spleen cells from an immunized mouse. -
克隆
单克隆 -
克隆编号
MM0054-11A7 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab78415于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/100 - 1/1000. Predicted molecular weight: 57 kDa.
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IHC-P |
1/50.
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说明 |
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WB
1/100 - 1/1000. Predicted molecular weight: 57 kDa. |
IHC-P
1/50. |
靶标
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功能
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2. -
组织特异性
Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. -
序列相似性
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain. -
翻译后修饰
Autophosphorylated. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 91 Human
- Omim: 601300 Human
- SwissProt: P36896 Human
- Unigene: 438918 Human
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形式
There are 3 isoforms produced by alternative splicing. Isoform 1 also known as SKR2-1; isoform 2 as SKR2-2; isoform 3 as SKR2-3. -
别名
- Activin A receptor type 1B antibody
- Activin A receptor type II like kinase 4 antibody
- Activin A type 1B receptor antibody
see all
图片
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Anti-Activin A Receptor Type IB/ALK-4 antibody [MM0054-11A7] (ab78415) at 1/100 dilution + Human embryonic tissue lysate
Predicted band size: 57 kDa
Observed band size: 58 kDa why is the actual band size different from the predicted? -
ab78415 at 1/50 dilution, staining Activin A Receptor Type IB/ALK-4 in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).
数据表及文件
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Datasheet download
文献 (1)
ab78415 被引用在 1 文献中.
- Tengroth L et al. Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps. Sci Rep 8:1561 (2018). PubMed: 29367682