Anti-ATP8B1抗体(ab121576)
Key features and details
- Rabbit polyclonal to ATP8B1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ATP8B1抗体
参阅全部 ATP8B1 一抗 -
描述
兔多克隆抗体to ATP8B1 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
KIWVLTGDKK ETAENIGFAC ELLTEDTTIC YGEDINSLLH ARMENQRNRG GVYAKFAPPV QESFFPPGGN RALII internal sequence amino acids 727-801 of Human ATP8B1.
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阳性对照
- IHC-P: Human lymph node, liver, kidney and cerebral cortex tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab121576于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.
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说明 |
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IHC-P
1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval. |
靶标
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功能
May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both. -
组织特异性
Found in most tissues except brain and skeletal muscle. Most abundant in pancreas and small intestine. -
疾病相关
Defects in ATP8B1 are the cause of progressive familial intrahepatic cholestasis type 1 (PFIC1) [MIM:211600]; also known as Byler disease. PFIC1 is an autosomal recessive disorder, characterized by early infancy cholestasis, that may be initially episodic but progresses to malnutrition, growth retardation and end-stage liver disease before adulthood.
Defects in ATP8B1 are the cause of benign recurrent intrahepatic cholestasis type 1 (BRIC1) [MIM:243300]; also known as Summerskill syndrome. BRIC is characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration. Patients are asymptomatic between episodes, both clinically and biochemically.
Defects in ATP8B1 can be associated with intrahepatic cholestasis of pregnancy (ICP) [MIM:147480]; also known as pregnancy-related cholestasis. ICP is a multifactorial liver disorder of pregnancy. It presents during the second or, more commonly, the third trimestre of pregnancy with intense pruritus which becomes more severe with advancing gestation and cholestasis. Cholestasis results from abnormal biliary transport from the liver into the small intestine. ICP causes fetal distress, spontaneous premature delivery and intrauterine death. ICP patients have spontaneous and progressive disappearance of cholestasis after delivery. -
序列相似性
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 5205 Human
- Omim: 602397 Human
- SwissProt: O43520 Human
- Unigene: 216623 Human
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别名
- AT8B1_HUMAN antibody
- ATP8B1 antibody
- ATPase class I type 8B member 1 antibody
see all
图片
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Immunohistochemical analysis of human cerebral cortex tissue labeling ATP8B1 with ab121576 at 1/20 dilution.
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Immunohistochemical analysis of human kidney tissue labeling ATP8B1 with ab121576 at 1/20 dilution.
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Immunohistochemical analysis of human liver tissue labeling ATP8B1 with ab121576 at 1/20 dilution.
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Immunohistochemical analysis of human lymph node tissue labeling ATP8B1 with ab121576 at 1/20 dilution.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab121576 尚未被引用在任何文献中。