Anti-8 Hydroxyguanosine抗体[3H30] (ab17647)

概述

  • 产品名称Anti-8 Hydroxyguanosine抗体[3H30]
    参阅全部 8 Hydroxyguanosine 一抗
  • 描述
    小鼠单克隆抗体[3H30] to 8 Hydroxyguanosine
  • 特异性Recognizes 8 Hydroxy-2'dexoyguanosine, 8 Hydroxyguanine and 8 Hydroxyguanosine from all species.
  • 经测试应用适用于: ELISAmore details
  • 种属反应性
    Reacts with a wide range of species.
  • 免疫原

    8 Hydroxyguanosine, BSA and casein coupled.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液pH: 7.40
    Preservative: 0.09% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号3H30
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab17647 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use a concentration of 0.1 - 5 µg/ml.

靶标

  • 相关性8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer’s disease. 8OHdG has become increasing popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA. Biomonitoring in humans has demonstrated that 8OHdG can be excreted in the urine, and that a significant increase is caused by exposure to tobacco smoke and ionizing radiation. Because 8OHdG is so well correlated with oxidative stress and damage to DNA, which leads to degenerative disease states, the development of an antibody that can be used to study DNA damage has numerous applications. In addition to the direct study of DNA damage within cells, this antibody has applications in the development of immunoassays that can monitor 8OHdG excretion in the urine and serve as a biomarker of oxidative stress.
  • 别名
    • 8 hydroxy 2’ deoxyguanosine antibody
    • 8 hydroxyguanine antibody
    • 8 hydroxyguanosine antibody
    • 8 OHG antibody
    • 8-OHG antibody
    • 8OG antibody
    • 8OHdG antibody
    • 8OHG antibody
    see all

Anti-8 Hydroxyguanosine antibody [3H30] (ab17647)参考文献

ab17647 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry regarding ab17647 (Anti-8 Hydroxyguanosine antibody [3H30]) and your patience. The concentration of this antibody is ~6.7 nmoles/ml. 1mg/ml / (150,000g/mole IgG) x 10e-3g/mg = 6.7 x 10e-9 moles/ml. I can confi...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"