5-Iodo A85380 dihydrochloride (ab120599)

概述

  • 产品名称5-Iodo A85380 dihydrochloride
  • 描述
    Potent α4β2 and α6β2 receptor agonist
  • 生物学描述Potent α4β2 and α6β2 receptor agonist (Ki = 0.2 nM at α4β2). 850 and 27000-fold more potent at α4β2 than α3β4 and α7, respectively. Shows antidepressant effects. Active in vivo.
  • 纯度> 98%

性能

  • 化学名称3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridine dihydrochloride
  • 分子量363.03
  • 化学结构Chemical Structure
  • 分子式C9H11IN2O.2HCl
  • CAS编号1217837-17-6
  • 存放说明Store at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in water to 100 mM and DMSO to 100 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCl.Cl.Ic1cc(cnc1)OC[C@@H]2CCN2
  • 来源

    Synthetic

  • 研究领域

    5-Iodo A85380 dihydrochloride (ab120599)参考文献

    This product has been referenced in:
    • Caldarone BJ  et al. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology (Berl) 217:199-210 (2011). Read more (PubMed: 21487659) »
    • Mogg AJ  et al. Functional responses and subunit composition of presynaptic nicotinic receptor subtypes explored using the novel agonist 5-iodo-A-85380. Neuropharmacology 47:848-59 (2004). Read more (PubMed: 15527819) »
    • Mukhin AG  et al. 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol 57:642-9 (2000). Read more (PubMed: 10692507) »

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