5-Azacytidine,DNMT1抑制剂(ab142744)
Key features and details
- Potent DNMT1 inhibitor. Induces DNA hypomethylation.
- CAS Number: 320-67-2
- Purity: > 98%
- Soluble in water to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
5-Azacytidine,DNMT1抑制剂 -
描述
Potent DNMT1抑制剂. Induces DNA hypomethylation. -
别名
- 5-AzadCyD
- Dacogen
- NSC 102816
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纯度
> 98% -
CAS编号
320-67-2 -
化学结构
性能
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化学名称
4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one -
分子量
244.21 -
分子式
C8H12N4O5 -
PubChem识别号
9444 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 50 mM and in DMSO to 100 mM -
处理
Unstable; make up solutions fresh and use immediately.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N -
来源
Synthetic
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研究领域
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (9)
ab142744 被引用在 9 文献中.
- Mainwaring OJ et al. ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors. Nat Commun 14:1221 (2023). PubMed: 36869047
- Jiang Y et al. Methyl-cpg-binding Domain Protein 2 Silencing Inhibits Th17 Differentiation of CD4+T cells Induced by Ovalbumin. Iran J Immunol 20:45-56 (2023). PubMed: 36932919
- Cossec JC et al. Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures. Cell Rep 42:112380 (2023). PubMed: 37061916
- Nam H et al. Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα. Nat Commun 13:1972 (2022). PubMed: 35418126
- Schwenzer H et al. LARP1 isoform expression in human cancer cell lines. RNA Biol 18:237-247 (2021). PubMed: 32286153
- Alarcón MA et al. The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer. Int J Mol Sci 21:N/A (2020). PubMed: 33322837
- Chen J et al. 5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And Apoptosis. Cancer Manag Res 11:9517-9528 (2019). PubMed: 31807076
- Fort RS et al. Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth. BMC Cancer 18:127 (2018). PubMed: 29394925
- Jacobs AH The skin in childhood. Hosp Pract 12:91-112 (1977). PubMed: 142744