生物学描述Selective PI3K inhibitor. Inhibits the initial phase of the autophagy. Blocks autophagosome formation. Potentiates apoptosis. Inhibits protein degradation (IC50 = 5 mM, rat hepatocytes).
存放说明Store at +4°C. The product can be stored for up to 12 months.
溶解度概述Soluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Seglen PO & Gordon PB 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A79:1889-92 (1982).
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