2-Furoyl-LIGRLO-amide (2Fly) (ab120800)

概述

  • 产品名称
    2-Furoyl-LIGRLO-amide (2Fly)
  • 描述
    Potent and selective PAR2 agonist
  • 别名
    • 2Fly
  • 生物学描述
    Potent and selective PAR2 receptor agonist (EC50 = 340 nM). Induces arterial contraction. Facilitates capsaicin evoked nociception. Around 100 times more potent than SLIGR-NH2 (ab120176).
  • 纯度
    > 95%

性能

  • 分子量
    777.96
  • 化学结构
    Chemical Structure
  • 分子式
    C36H63N11O8
  • CAS编号
    729589-58-6
  • 序列
    LIGRLX (Modifications: N-terminal 2-Furoyl; C-terminal amide; X-6 = Orn)
  • 存放说明
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述
    Soluble in water to 1 mg/ml
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 来源

    Synthetic

  • 研究领域

文献

This product has been referenced in:
  • Hollenberg MD  et al. Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization. J Pharmacol Exp Ther 326:453-62 (2008). Read more (PubMed: 18477767) »
  • Saifeddine M  et al. Proteinase-activated receptor-2 activating peptides: distinct canine coronary artery receptor systems. Am J Physiol Heart Circ Physiol 293:H3279-89 (2007). Read more (PubMed: 17766477) »
  • Kawabata A  et al. Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin. Neurosci Lett 402:167-72 (2006). Read more (PubMed: 16644120) »
  • McGuire JJ  et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther 309:1124-31 (2004). Read more (PubMed: 14976230) »

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