Anti-17 beta Estradiol 3抗体(ab50660)

概述

  • 产品名称Anti-17 beta Estradiol 3抗体
  • 描述
    山羊多克隆抗体to 17 beta Estradiol 3
  • 特异性Cross reactivities with related molecules; Estrone < 1%, Estriol < 1%, Testosterone < 1%, DHEA < 1%, Androstenedione 0%.
  • 经测试应用适用于: RIA, ELISAmore details
  • 免疫原

    17ß Estradiol-3 conjugated to BSA

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: Whole serum
  • 纯度Whole antiserum
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab50660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
RIA
ELISA
  • 应用说明EIA: Titre 1/1100000.
    RIA: Titre 1/1100000.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性17 beta estradiol is an estrogenic hormone, C18H24O2, produced by the ovaries and used in treating estrogen deficiency and breast cancer. Estradiol, like other sex steroids, is derived from cholesterol. After side chain cleavage and either utilizing the delta-5 pathway or the delta-4 pathway androstenedione is the key intermediary. Androstendione is either converted to testosterone which in turn undergoes aromatization to estradiol, or, alternatively, androstendione is aromatized to estrone which is converted to estradiol. During the reproductive years most estradiol in women is produced by the granulosa cells of the ovaries by aromatization of testosterone from the theca cells, or conversion of estrone to estradiol. Smaller amounts of estradiol are also produced by the adrenal cortex. In men, the testes produce some estradiol. An additional source of estradiol in both sexes is peripheral aromatization of testosterone to estradiol. Particularly fat cells are active to convert precursors to estradiol, and will continue to do so even after the menopause. Estradiol enters cells freely and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell.
    • 细胞定位Secreted

    Anti-17 beta Estradiol 3 antibody (ab50660)参考文献

    ab50660 has not yet been referenced specifically in any publications.

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    Thank you for contacting Abcam.
    We guarantee ab50660 to work in RIA, Enzyme Immunoassays. If you wish to test the antibody in another application apart from these, then you would qualify for our testing discount program. The link below provides mo...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"