概述

  • 产品名称Anti-14-3-3 Tau抗体
    参阅全部 14-3-3 Tau 一抗
  • 描述
    山羊多克隆抗体to 14-3-3 Tau
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Chicken, Cow, Pig, Xenopus laevis, Orangutan
  • 免疫原

    Synthetic peptide corresponding to Human 14-3-3 Tau aa 136-146 (internal sequence).
    Sequence:

    C-DDRKQTIDNSQ


    Database link: NP_006817.1

  • 阳性对照
    • WB: Human Brain (Hippocampus) lysate.

性能

应用

Our Abpromise guarantee covers the use of ab77268 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 28 kDa).
ELISA Use at an assay dependent concentration.

Peptide ELISA: Antibody detection limit dilution 1/4,000. 

靶标

  • 功能Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
  • 组织特异性Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
  • 序列相似性Belongs to the 14-3-3 family.
  • 翻译后修饰Ser-232 is probably phosphorylated by CK1.
  • 细胞定位Cytoplasm. In neurons, axonally transported to the nerve terminals.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 14 3 3 protein T cell antibody
    • 14 3 3 protein tau antibody
    • 14 3 3 protein theta antibody
    • 14 3 3 tau antibody
    • 14 3 3 theta antibody
    • 14-3-3 protein T-cell antibody
    • 14-3-3 protein tau antibody
    • 14-3-3 protein theta antibody
    • 1433T_HUMAN antibody
    • 1C5 antibody
    • HS1 antibody
    • KCIP1 antibody
    • Protein HS1 antibody
    • Protein kinase C inhibitor protein 1 antibody
    • Protein tau antibody
    • tyr3/trp5 monooxygenase activation protein, theta antibody
    • Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptide antibody
    • Ywhaq antibody
    see all

Anti-14-3-3 Tau antibody 图像

  • Anti-14-3-3 Tau antibody (ab77268) at 0.03 µg/ml + Human Brain (Hippocampus) in RIPA buffer at 35 µg

    Predicted band size : 28 kDa
    Observed band size : 28 kDa

Anti-14-3-3 Tau antibody (ab77268)参考文献

ab77268 has not yet been referenced specifically in any publications.

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