Anti-14-3-3 beta + zeta抗体[4E2] (ab14114)

概述

  • 产品名称Anti-14-3-3 beta + zeta抗体[4E2]
    参阅全部 14-3-3 beta + zeta 一抗
  • 描述
    小鼠单克隆抗体[4E2] to 14-3-3 beta + zeta
  • 经测试应用适用于: WB, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Sheep, Cow, Dog, Human, Pig, Monkey
  • 免疫原

    Tissue/ cell preparation (Lysed transformed human amnion cells).

  • 阳性对照
    • HeLa cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab14114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa.
ICC 1/50.

靶标

  • 相关性14-3-3 proteins are highly conserved proteins which play a role in both signal transduction and progression through the cell cycle by binding to and regulating several different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta, and eta. An eighth subtype, termed theta has been found in rat brain. The 14-3-3 proteins exists in vitro and in vivo as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C. 14-3-3 proteins are localized in the cytoplasm of neurons in the cerebral cortex and are axonally transported to the nerve terminals. They may be present at lower levels in various other eukaryotic tissues. Northern blot analysis has shown expression of the eta chain in cultured cell lines derived from various tumors.
  • 细胞定位Cytoplasmic. Melanosome (fractions from stage I to stage IV)
  • 数据库链接
  • 别名
    • 14 3 3 protein beta antibody
    • 14 3 3 protein beta/alpha antibody
    • 14 3 3 protein zeta/delta antibody
    • 14 3 3 zeta antibody
    • HS1 antibody
    • KCIP1 antibody
    • YWHAB antibody
    • YWHAZ antibody
    see all

Anti-14-3-3 beta + zeta antibody [4E2] (ab14114)参考文献

ab14114 has not yet been referenced specifically in any publications.

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