Anti-14-3-3抗体(ab30579)

概述

  • 产品名称Anti-14-3-3抗体
    参阅全部 14-3-3 一抗
  • 描述
    兔多克隆抗体to 14-3-3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human, Xenopus laevis
  • 免疫原

    Synthetic peptide corresponding to amino acid residues from the C terminal region of 14-3-3 protein, conjugated to keyhole limpet hemocyanin (KLH). Human.

  • 阳性对照
    • rat brain hippocampus lysate
  • 常规说明


    Immunolabeling of the 14-3-3 protein band is completely blocked by pre-adsorption of the antibody with the C-terminal peptide that was used to generate the antibody.

性能

应用

Our Abpromise guarantee covers the use of ab30579 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 30 kDa.

靶标

  • 功能Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
  • 序列相似性Belongs to the 14-3-3 family.
  • 翻译后修饰The alpha, brain-specific form differs from the beta form in being phosphorylated (By similarity). Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
    Isoform Short contains a N-acetylmethionine at position 1.
  • 细胞定位Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 14 3 3 antibody
    • 14 3 3 protein beta antibody
    • 14 3 3 protein beta/alpha antibody
    • 14 3 3 protein zeta antibody
    • 14 3 3 zeta antibody
    • 14-3-3 protein beta/alpha antibody
    • 14-3-3 protein/cytosolic phospholipase A2 antibody
    • 1433B_HUMAN antibody
    • GW128 antibody
    • HS1 antibody
    • KCIP 1 antibody
    • KCIP-1 antibody
    • MGC111427 antibody
    • MGC126532 antibody
    • MGC138156 antibody
    • N-terminally processed antibody
    • Protein 1054 antibody
    • Protein kinase C inhibitor protein 1 antibody
    • Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide antibody
    • Tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide antibody
    • YWHAB antibody
    • YWHAD antibody
    • YWHAZ antibody
    see all

Anti-14-3-3 antibody 图像

  • Anti-14-3-3 antibody (ab30579) at 1/1000 dilution + rat brain hippocampus lysate

    Predicted band size : 30 kDa

Anti-14-3-3 antibody (ab30579)参考文献

ab30579 has not yet been referenced specifically in any publications.

Product Wall

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ab30579 is specific for the 14-3-3 protein zeta/delta isoform.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"