概述

  • 产品名称
    (-)-Deguelin
  • 描述
    Akt inhibitor. Anticancer agent.
  • 别名
    • (-)-cis-Deguelin
  • 生物学描述
    Akt inhibitor. Anticancer agent. Inhibits cell growth (IC50 = 43.2 nM) in vitro. Anticancer and antiangiogenic activities in vivo.
  • 纯度
    > 98%

性能

  • 化学名称
    (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
  • 分子量
    394.42
  • 化学结构
    Chemical Structure
  • 分子式
    C23H22O6
  • CAS编号
    522-17-8
  • 存放说明
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述
    Soluble in DMSO to 50 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    COc1cc2c(OC[C@H]3Oc4c(ccc5OC(C)(C)C=Cc45)C(=O)[C@@H]23)cc1OC
  • 来源

    Synthetic

  • 研究领域

文献

This product has been referenced in:
  • Kang HW  et al. Deguelin, an Akt inhibitor, down-regulates NF-?B signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice. Dig Dis Sci 57:2873-82 (2012). Read more (PubMed: 22623043) »
  • Oh SH  et al. Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha. Int J Cancer 122:5-14 (2008). Read more (PubMed: 17764071) »
  • Murillo G  et al. Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer 38:2446-54 (2002). Read more (PubMed: 12460790) »

See 0 Publications for this product

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