(-)-Bicuculline methobromide,GABAA拮抗剂(ab120109)
Key features and details
- GABAA antagonist
- CAS Number: 73604-30-5
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
(-)-Bicuculline methobromide,GABAA拮抗剂 -
描述
GABAA拮抗剂 -
CAS编号
73604-30-5 -
化学结构
性能
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化学名称
[S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide -
分子量
462.29 -
分子式
C21H20BrNO6 -
PubChem识别号
171729 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[N+]1(CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3)C.[Br-] -
来源
Synthetic
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研究领域
相关产品
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图片
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2D chemical structure image of ab120109, (-)-Bicuculline methobromide, GABAA antagonist
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Saturation of LTP by nicotine application.
VSD recordings were performed from the granular layer of cerebellar slices (pre-treated with 10 µM bicuculline methobromide) to measure the spatial organisation of the effect of nicotine following TBS.
(Panel A) Images of background epifluorescence in stained cerebellar slices show the granular layer (GRL), Purkinje cell layer (PCL), molecular layer (ML), mossy fibre bundle (mf), and position of the stimulating electrode (yellow dots). Coloured optical maps of granular layer activity evoked by a single mossy fibre pulse are compared before and after the induction of long-term synaptic plasticity by TBS.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (11)
ab120109 被引用在 11 文献中.
- Oku S et al. Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity. Elife 9:N/A (2020). PubMed: 32915137
- Chittajallu R et al. Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells. Elife 9:N/A (2020). PubMed: 32496194
- Ge Y et al. Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength. Neuron 97:596-610.e8 (2018). PubMed: 29395912
- Zhang P et al. Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships. Cell 174:1450-1464.e23 (2018). PubMed: 30100184
- Kosillo P et al. Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons. Cereb Cortex N/A:N/A (2016). PubMed: 27566978